Partnering with microbiologists to diagnose and prevent diseaseTM

A new way to control C. diff.


Microbytes logo tm

Hardy Logo White                  


a culture of service…

January, 2017


© 2017, Hardy Diagnostics,

all rights reserved 


For long term preservation…




  • Ideal for freezer storage of all microorganisms
  • Contains a glycerol cryopreservative medium
  • Available in many colors
  • With or without plastic beads
  • Brucella Broth or Skim Milk
See the brochure.
View the video.
*  *  *

Check out our Insta-Gram…
No Mess!
No Stress!
Hardy’s GramPRO 1 will rapidly stain your smears and get it right every time! Our patented technology judges the thickness of the smear and adjusts the decolorization step to perfection. Not only that, there are no messy clean-up or maintenance procedures. The GramPRO 1 will produce a perfect slide every time in about 4 minutes.




Find out more about the GramPRO 1.


Watch a brief video on GramPRO 1.


View the brochure on all of Hardy’s automated stainers.



Please contact me to discuss automated slide stainers.







Showing 2,700 products!


Hardy’s Culture
Media Catalog


Hardy is proud to announce its new catalog of all culture media offerings.
This 85 page booklet contains descriptions of the 2,700 products that Hardy manufactures for the microbiologist.
View the digital version.
Send me the paper version.
Please have an account rep contact me about a price quote.

*  *  *









Let’s get rapid…













Rapid Test Catalog
View our online catalog detailing hundreds of rapid tests for microbial identification.
Request our paper version.
*  *  *

Kirby Bauer disks…


HardyDisk AST


Hardy’s Kirby Bauer Diffusion Disks offer:
  • Complete selection of common antibiotics
  • “Last Disk” recognition to warn you to change to a new cartridge
  • Packaged in space-saving canisters with built-in desiccants
  • Compatibility with your BD disk dispenser
View all our susceptibility products.
Order now!
MH plate





Sharpen your brain here…

Bagpipe Lung


 Celtic musicians were shocked to learn that one of their fellow bagpipers died recently due to what has become known as “Bagpipe Lung.” This disease was thought to have been caused by hypersensitivity pneumonitis as a reaction to fungi growing within his instrument. 
The case has led doctors to propose that “bagpipe lung” be added to the long list of alternative monikers for hypersensitivity pneumonitis, which is already known as “bird fancier’s lung,” “farmer’s lung,” and even “hot tub lung” after the wide range of activities to which it has previously been linked. These diseases are triggered by an extreme immune response due to contamination with bacteria or fungi.
The 61 year old victim was known to play his bagpipes daily. An investigation revealed that his bagpipes were contaminated with mold spores. Inside the air bag a mixture of Paecilomyces variotti, Fusarium oxysporum, Rhodotorula mucilaginosa, and Penicillium species were isolated. Although he died in 2014, he was not fully diagnosed until two years later.
Warnings have been issued to all wind and brass instrument musicians to perform regular cleanings.  Saxophone and trombone players have rarely been reported to suffer from the same disease. 

Think about it…
The Thinker




How come you never hear father-in-law jokes?

* The statistics on sanity is that one out of every four persons are suffering from some sort of mental illness. Think of your three best friends — if  they’re okay…then it’s you.
* Why does a round pizza come in a square box?
* What disease did cured ham actually have?
*  How is it that we put man on the moon before we figured out it would be a good idea to put wheels on luggage? 






* * *

Wisdom to Ponder…
Julia Child
1912 ~ 2004
Chef, author, and TV personality. With great joy and style she brought French cooking into American homes as the first modern day celebrity chef.
“Drama is very important in life: You have to come on with a bang. You never want to go out with a whimper. Everything can have drama if it’s done right. Even a pancake.”
“You learn to cook so that you don’t have to be a slave to recipes. You get what’s in season and you know what to do with it.”
“Because of media hype and woefully inadequate information, too many people nowadays are deathly afraid of their food, and what does fear of food do to the digestive system? I am sure that an unhappy or suspicious stomach, constricted and uneasy with worry, cannot digest properly.”
“Being tall is an advantage, especially in business. People will always remember you. And if you’re in a crowd, you’ll always have some clean air to breathe.”
“The only time to eat diet food is while you’re waiting for the steak to cook.”
“Life itself is the proper binge.”


* * *


“I must be willing to give up what I am,
 in order to become what I will be.”
Albert Einstein
 Albert Einstein.



Online Ordering Made Easy! 




Online ordering
Watch a short video
to learn how easy it is
to order from Hardy on-line!


Pick. Click. You’re Done!


  * * *

Did you know? 


Hardy Diagnostics…
  • Is celebrating its 36th year of serving microbiologists.
  • Manufactures from three ISO certified factories; one in California, Ohio, and Texas.
  • Is ISO 13485 certified for the manufacture of medical devices to give you confidence in our products.
  • Services over 10,000 labs and maintains a worldwide network of over 65 distributors.
  • Is a 100% Employee-Owned company. “If we act like we own the place…it’s because we do!”
Blue Logo




Hardy Logo White


Microbytes logo tm


Want to receive the MicroBytes
Newsletter at home?


Want to view past issues
of MicroBytes?


Hardy Diagnostics

Cats are smarter than dogs.
You’ll never find eight cats
to pull a sled through snow.


Following an argument, an angry Lady Astor once told Winston Churchill, “Winston, if you were my husband, I’d put poison in your coffee.”
Churchill snapped back, “If you were my wife, I’d drink it.”


“As Hardy Diagnostics enters its 37th year of serving microbiologists in the laboratory, I would like to thank each of our customers for their support and loyalty. It truly has been a pleasure to serve you!
If there is any way we can improve or expand upon our service, would you please let me know?”



Jay's photo 2
Jay Hardy, CLS, SM(NRCM)


Micro Musings…



Keeping you young and healthy…


Nature’s Trash Recycling Service

Did You Know You Are Autophagic?  And that’s a good thing, since it slows down aging and prevents degenerative diseases.
For illuminating the weird cellular phenomenon of “self-eating,” Yoshinori Ohsumi has won the 2016 Nobel Prize in Physiology or Medicine.  Called autophagy – from the Greek words “auto” and “phagein,” meaning “self” and “to eat” – the process allows cells to destroy their own guts and essentially recycle them.
Autophagy is the natural, destructive mechanism that disassembles, through a regulated process, unnecessary or dysfunctional cellular components.  It refers to the process in which cellular junk is captured and sealed in sack-like membranes, called autophagosomes. The sealed contents are transported to another structure called the lysosome, once considered little more than the cellular rubbish bin.
Our cells have various organelles and lysosomes constitute one such structure that contains enzymes for digestion of cellular contents. Recently a new type of vesicle called autophagosome was observed within the cell. As the autophagosome forms, it engulfs cellular contents, such as damaged proteins and organelles. Finally, it fuses with the lysosome, where the contents are degraded into smaller constituents (pictured above). This process provides the cell with nutrients and building blocks for renewal.
Little was known about the odd behavior until Dr. Ohsumi’s brilliant experiments in the early 1990s.  In these experiments, the Fukuoka, Japan-born scientist identified genes in yeast that were crucial to autophagy, revealing the underlying mechanisms of the process in yeast and showing that similar mechanisms were used in human cells.
One mystery that remained, however, was how the cell ditched and recycled larger protein complexes and wearied organelles. That’s where Dr. Ohsumi’s experiments came into play.  By culturing mutated yeast that lacked enzymes used for degradation in the vacuole, while simultaneously starving the cells to trigger autophagy, Dr. Ohsumi was able to observe vacuoles filled with small vesicles that hadn’t been degraded.  He proved that autophagy occurs in yeast cells and went on to identify the genes involved in the process and how they come together to build the autophagosome membrane.  The results showed that autophagy is controlled by a cascade of proteins and protein complexes, each regulating a distinct stage of autophagosome initiation and formation.
He later showed that a similar cellular recycling process occurs in human cells – and that our cells would not survive without it.  The process is critical for cells to survive and to stay healthy.
Thanks to Dr. Ohsumi and others following in his footsteps, we now know that autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress.  Autophagy also plays a housekeeping role in removing damaged cell components such as clearing damaged mitochondria or misfolded proteins, as well as eliminating intracellular pathogens.   During starvation, cells break down proteins and non-essential components and reuse them for energy.  Autophagy is the body’s internal recycling program – scrap cell components are captured and the useful parts are stripped out to generate energy or build new cells.  It contributes to embryo development and cell differentiation.  As well, the process is crucial for preventing cancerous growths, warding off infection and, by maintaining a healthy metabolism, it helps protect against conditions like diabetes and dementia.  The failure of autophagy is thought to be one of the main reasons for the accumulation of cell damage and aging.
Disrupted autophagy has been linked to auto-immune disease, genetic diseases and neurodegenerative disorders such as Huntington’s, Alzheimer’s and Parkinson’s disease, infectious diseases, heart disease, type 2 diabetes, cancer and a host of age-related disorders. Intense research is now ongoing to develop drugs that can target autophagy in various diseases.  Thus, autophagy has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant.
Dr. Ohsumi said he chose to focus on the cell’s waste disposal system, an unfashionable subject at the time, because he wanted to work on something different.  “I find it more enjoyable doing something nobody else is doing.  In a way, that’s what science is all about, the joy of finding something that inspires you.”  His discoveries have provided deep insights into the biology underpinning many diseases and are paving the way for new approaches to treating them.
By Corrie Landymore-Dodson
* * * * *
Nobel Prize winner. The Nobel Prize in Physiology or Medicine 2016.  Nobel Karolinska Institutet. Retrieved 3 October 2016.
J. Pathol. 2010 May: 221 (1): 3-12.
Cuervo, A.M. et al. 2005. Autophagy and Aging: The Importance of Maintaining “Clean Cells”. Autophagy. 1 (3): 131-140.

For environmental monitoring . . .
C diff
Banana Broth
Hardy announces a new medium for the detection of
Clostridium difficile bacteria and spores. This new medium is capable of saving hospitals many thousands of dollars. It is useful in monitoring the effectiveness of cleaning procedures used in patient rooms. This is the first and only culture medium that is designed for the detection of C. difficile and its spores on surfaces in a hospital setting.  The specificity was found to be 100% in a recent study (see reference below). No special equipment or anaerobic supplies are needed! Obtain results in as little as 24 hours!
View a short video explaining how C. diff Banana Broth can save your hospital many thousands of dollars!
Request a sample for your evaluation.
* * * * *
Hardy announces 
a new chromogenic medium….


Hardy Diagnostics is pleased to inform our customers that HardyCHROM ESBL (Cat No. G321) has recently received clearance from the FDA.

ESBL E. coli on the new HardyCHROM ESBL Agar plate.


ESBL Klebsiella pneumoniae on HardyCHROM ESBL.


HardyCHROM ESBL serves as a selective and differential chromogenic medium containing a broad-spectrum beta-lactam intended for the qualitative and presumptive detection of K. pneumoniae, K. oxytoca, and E. coli that produce an extended-spectrum beta-lactamase (ESBL). In addition, it tests for Enterobacteriaceae that are potentially non-susceptible to broad-spectrum cephalosporins. 


This chromogenic medium is to be used with fecal specimens and is intended as an aid in the detection, identification of colonization, and control of these bacteria in a healthcare setting.


Subculture to non-selective media is required for confirming identification, antimicrobial susceptibility testing, and epidemiological typing.


Hardy is the only media manufacturer to offer a selective medium to detect ESBLs. To try a sample of HardyCHROM ESBL in your lab, inquire about HardyCHROM ESBL with your Sales Rep today!


Find more information  on HardyCHROM ESBL.




Request for samples for evaluation.


See all of Hardy’s Chromogenic Media.



* * *
Trio Bas
Air Samplers
Two heads are better than one!
Now with Bluetooth capability!
Trio Bas from Orum International has a robust impact air sampler for every type of use. Single, double, or triple heads are available from Hardy Diagnostics.
Watch a short video that will explain why the Trio Bas is the best choice for your clean room.
air samplers.
 * * *

Weird things to do when no one is watching…
Why is it that when you pinch your elbow skin 
as hard as you can, it doesn’t hurt?


Go ahead and try it…
Scroll to bottom of this column to find out why…




Optical oddities… 


Angry Man ~ Pleasant Man
The one one the left is angry…right?
Now back away slowly from your
computer about 10 feet or so.
Who is the angry man now?





  “Believe half of what you see

and none of what you hear.”

 ~ Benjamin Franklin ~

HC MRSA plate
for brighter, more distinct color reactions.
Learn more…
Purchase now from our online catalog.
See all chromogenic media.
Call me for more info and pricing.
Request for free samples.




Find more

of Leigh Rubin’s cartoon humor.

Want to book Leigh as a speaker at your next event?


Smaller babies may be delivered by stork, but the heavier ones need a crane.
Sleeping comes so naturally to me, I could do it with my eyes closed.
I was going to buy a book on phobias, but I was afraid it wouldn’t help me.
I once took a picture of a field of wheat, but it was too grainy.
I used to be addicted to soap, but I’m clean now.
#  #  #


How’s that again?
“A verbal contract isn’t worth the paper it’s written on.” ~ Samuel Goldwyn
“I have made good judgments in the past. I have made good judgments in the future.” ~ Dan Quayle
“I have opinions of my own, strong opinions, but I don’t always agree with them.” ~ George H. W. Bush


“That scoundrel deserves to be kicked to death by a jackass, and I’m just the one to do it.”  ~ A congressional candidate in Texas


“So, where’s the Cannes Film Festival being held this year?” ~ Christina Aguilera
“I haven’t committed a crime. What I did was fail to comply with the law.” ~ David Dinkins, New York City Mayor




The sign of a truly beautiful person, 
is that they also see beauty in others.



The reason why pinching your elbow skin doesn’t hurt is because you have different types of nerve receptors in your skin; some for pressure sensing, heat, cold, and sharp pain.  Tough skin, like that on elbows, has fewer pressure pain detectors, because your elbow is often being leaned on while touching a surface. Parts of your body at a higher risk from being damaged have more nerve endings, so are more sensitive, such as your fingers.


Like me on FacebookView my profile on LinkedInFollow me on TwitterView my videos on YouTubeFind me on PinterestVisit my blog