We’re all familiar with this ever-present dichotomy. Antibiotics are life-saving, until they’re not; until the delicate balance shifts, causing the oh-so-inevitable resistance. While antibiotic stewardship programs are becoming more and more prevalent, what does one do when working with a patient with a chronic condition in which daily, long-term antimicrobial treatment is the norm? How do we address antimicrobial resistance (AMR) in patients with whom bacterial infections are typically never fully eradicated, despite the employment of a multitude of drug therapies?

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